HBS can mean:
- Harvard Business School
- Hrvatski Biciklisticki Savez, the Croatian Cycling Federation
- Henrietta Barnett School
- Hitchin Boys' School
- Hogere burgerschool, a Dutch educational type until 1968.
- HbS, the mutant form of hemoglobin (Hb) that leads to sickle-cell disease
- Heinrich-Böll-Stiftung (Heinrich Böll Foundation)
- Hoboken Shore Railroad
- hbs, the ISO 639-3 code for the Serbo-Croatian language
- Harry Benjamin Syndrome
- Hunan Broadcasting System
- HBS Craeyenhout, a Dutch sports team.
- HBS Craeyenhout (football club).
- Host Broadcast Services, a subsidiary of Infront Sports & Media.
HBS is a perhaps obsolete printing language or protocol used by network printers.