Gwen may refer to:
- Gwen (given name), including a list of people with the name
- Gwen, or the Book of Sand, a 1985 animated film
- Tropical Storm Gwen (disambiguation)
- Acronyms
- AN/URC-117 Ground Wave Emergency Network, a military command and control communications system
- Guild Wars: Eye of the North (GW:EN), an expansion pack for a massively multiplayer online role-playing game
- People
- Gwen Stefani, lead singer of the ska punk band No Doubt
- Fictional characters
- Gwen Cooper, from the TV series Torchwood
- Gwen Norbeck Munson, from the TV soap opera As the World Turns
- Gwen Raiden, from the TV series Angel
- Gwen Stacy, from the Marvel comics Spider-Man series
- Gwen Tennyson, from the TV series Ben 10
- Gwen Winthrop, from the TV soap opera Passions
- Gwen Wu, from the animated TV series The Mighty B!
- Gwen, from the American Girl doll collection
- Gwen, from the MMORPG Guild Wars, including Eye of the North
- Gwen, from the American animated series Mission Hill
- Gwen, from the animated TV series Total Drama Island
- Gwen Grayson, from the 2005 film Sky High
- Gwen West, from the TV sitcom Gavin & Stacey
- Gwen Meighen, an air stewardess from the 1968 novel Airport
- The same character in the 1970 film adaptation, Airport