Examples of GEFs
- Son of sevenless (SOS1) is an important GEF in the cell growth-regulatory MAPK/ERK pathway. SOS1 binds GBR2 at the plasma membrane after EGF receptor activation. SOS1 activates the small G protein Ras.
- eIF-2b is a eukaryotic initiation factor necessary to initiate protein translation. eIF-2b regenerates the GTP-bound form of eIF-2 for an additional cycle in protein synthesis initiation, i.e., its binding to the Met-t-RNA.
- G protein-coupled receptors are trans-membrane receptors that act as GEFs for their cognate G proteins upon binding of a ligand. Ligand binding induces a conformational change that allows the GPCR to activate an associated GTPase.
- RCC1 is the guanine nucletoot change factor for Ran GTPase. It localizes to the nucleus and catalyzes the activation of Ran to allow nuclear export of proteins.
- Ras-GRF1
- Kalirin
Read more about this topic: Guanine Nucleotide Exchange Factor
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