Guanine Nucleotide Exchange Factor

Guanine Nucleotide Exchange Factor

Guanine nucleotide exchange factors (GEFs) activate monomeric GTPases by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP). A variety of unrelated structural domains have been shown to exhibit guanine nucleotide exchange activity. Some GEFs can activate multiple GTPases while others are specific to a single GTPase.

Read more about Guanine Nucleotide Exchange Factor:  Function, Mechanism, Structure and Specificity, Regulation, GEFs and Cancer, Examples of GEFs

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