Graydon may refer to:
- Graydon Creed, a Marvel Comics supervillain
People with the given name Graydon:
- Benjamin Graydon Allmark (1911-2004), Canadian politician
- Graydon Carter (born 1949), Canadian-born American journalist and author
- Graydon Eggers (20th century), American football coach
- Graydon Evans (1908-1943), American test pilot
- Graydon Henning (21st century), Australian maritime historian
- Graydon Parrish (21st century), American figurative painter
People with the surname Graydon:
- Cliff Graydon (21st century), Canadian politician
- Gordon Graydon (1897-1953), Canadian politician
- Gordon Graydon (Alberta politician) (21st century), Canadian politician
- Jay Graydon (21st century), American record producer
- John Graydon (d. 1726), Royal Navy officer
- Michael Graydon (born 1938), Royal Air Force air marshal
- Ray Graydon (born 1947), English football manager