Goop may refer to:
- Goops, a 1900 book series by Gelett Burgess
- Shoe Goo or Sportsman's Goop, a brand of waterproof seam-sealer
- Goop, a character from Ben 10: Alien Force
- Goop, a lanolin-based hand cleaner
- Goop, a newsletter by Gwyneth Paltrow
- Plastigoop, a substance associated with Creepy Crawlers toys
- An ongoing project to add a dynamic object-orientated programming (OOP) layer to the go programming language.
- A magnesium dust paste in a kerosine and asphalt base used as an alternative to Napalm in World War 2 incendiary bombs.