Gokhale is an Indian surname typically found in the western state of Maharashtra amongst Chitpavan Kokanastha Brahmins. The supposed origin of the Gokhale clan was in the small coastal town of Velneshwar about 10km from Guhagar and 50km from Chiplun in the Konkan region. The etymology of the word is accepted to be from Marathi gokhla, meaning "round window", originally from Sanskrit gav-ākşa, literally "cow-eye".
- Gopal Krishna Gokhale, a leader in in the Indian independence struggle
- Vikram Gokhale, an actor
- Mohan Gokhale, an actor
- Gokhale Institute of Politics and Economics, an institute
- Shanta Gokhale, writer, translator, journalist, theatre critic
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