Glycogen Storage Disease Type V - The Reaction

The Reaction

Myophosphorylase is involved in the breakdown of glycogen to glucose for use in muscle. The enzyme removes 1,4 glycosyl residues from outer branches of glycogen and adds inorganic phosphate to form glucose-1-phosphate. Cells form glucose-1-phosphate instead of glucose during glycogen breakdown because the polar, phosphorylated glucose cannot leave the cell membrane and so is marked for intracellular catabolism.

Myophosphorylase exists in the active form when phosphorylated. The enzyme phosphorylase kinase plays a role in phosphorylating glycogen phosphorylase to activate it and another enzyme, protein phosphatase-1, inactivates glycogen phosphorylase through dephosphorylation.

Read more about this topic:  Glycogen Storage Disease Type V

Famous quotes containing the word reaction:

    Sole and self-commanded works,
    Fears not undermining days,
    Grows by decays,
    And, by the famous might that lurks
    In reaction and recoil,
    Makes flames to freeze, and ice to boil.
    Ralph Waldo Emerson (1803–1882)

    More and more, when faced with the world of men, the only reaction is one of individualism. Man alone is an end unto himself. Everything one tries to do for the common good ends in failure.
    Albert Camus (1913–1960)