Focal Segmental Glomerulosclerosis - Appearance

Appearance

The individual components of the name refer to the appearance of the kidney tissue on biopsy: focal—only some of the glomeruli are involved (as opposed to diffuse), segmental—only part of each glomerulus is involved (as opposed to global), glomerulosclerosis—refers to scarring of the glomerulus (a part of the nephron (the functional unit of the kidney)). The glomerulosclerosis is usually indicated by heavy PAS staining and findings of IgM and C3 in sclerotic segment.

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    What lies behind appearance is usually another appearance.
    Mason Cooley (b. 1927)

    The aim of science is to apprehend this purely intelligible world as a thing in itself, an object which is what it is independently of all thinking, and thus antithetical to the sensible world.... The world of thought is the universal, the timeless and spaceless, the absolutely necessary, whereas the world of sense is the contingent, the changing and moving appearance which somehow indicates or symbolizes it.
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    Every natural fact is a symbol of some spiritual fact. Every appearance in nature corresponds to some state of the mind, and that state of the mind can only be described by presenting that natural appearance as its picture.
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