Early History
Some of the earliest work in Flux Balance Analysis dates back to the early 1980s. Papoutsakis demonstrated that is was possible to construct flux balance equations using a metabolic map. It was Watson however who first introduced the idea of using linear programming and an objective function to solve for the fluxes in a pathway. The first significant study was subsequently published by Fell and Small who used flux balance analysis together with more elaborate objective functions to study the constraints in fat synthesis.
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