Flunitrazepam - Pharmacology

Pharmacology

Benzodiazepines, including flunitrazepam, bind to most glial cell membranes with high affinity in mouse astrocytes. Flunitrazepam induces melanogenesis in B16/C3 mouse melanoma cell cultures via modulating high-affinity binding sites. Benzodiazepines, including flunitrazepam have been shown to act on benzodiazepine binding sites as Ca2+ channel blockers and significantly inhibit depolarization-sensitive calcium uptake in rat brain cell components. This has been conjectured as a mechanism for high-dose effects against seizures in a study.

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