DRG, a three-letter acronym, may refer to:
- DRG London, a Digital Audio Broadcasting multiplex available in the London area
- DRG Technologies, a company based in Safford, Arizona
- Democratic Republic of Georgia, 1918–1921, was the first modern establishment of a Republic of Georgia
- Denver and Rio Grande Railroad
- Deutsche Reichsbahn-Gesellschaft, a predecessor of Deutsche Bahn
- Diagnosis-related group, a system to classify hospital cases
- Dickinson Robinson Group, British stationery manufacturers
- Digital raster graphic, a digital image
- Delaney Rovers GAA, a Gaelic Athletic Association club in Cork, Ireland
- DongRaeGu, a professional StarCraft II Zerg player from South Korea.
In biology:
- Dorsal respiratory group, in biology
- Dorsal root ganglion, in biology