Crosse is a surname, and may refer to:
- Andrew Crosse (1784–1855), British amateur scientist
- Charles Crosse, British rugby
- Charles G. Crosse, American physician and politician
- Damien Crosse (born 1982), Cuban-American pornographic actor
- Edmond Francis Crosse (1858-1941), first Archdeacon of Chesterfield
- John Crosse, English radio DJ, presenter and continuity announcer
- John Green Crosse (1790-1850), English surgeon
- Joseph Charles Hippolyte Crosse (1826-1898), a French conchologist
- Lavinia Crosse, founder of the Community of All Hallows religious order
- Roger Crosse, character in James Clavell's novel Noble House
- Rupert Crosse (1927-1973), American television and film actor
- Victoria Crosse, a pseudonym of novelist Annie Sophie Cory (1868–1952)