Further Work
Australian immunologist Frank Macfarlane Burnet with input from David W. Talmage worked on this model, and was the first to name it "clonal selection theory." Burnet explained immunological memory as the cloning of two types of lymphocyte. One clone acts immediately to combat infection whilst the other is longer lasting, remaining in the immune system for a long time, which results in immunity to that antigen. In 1958, Sir Gustav Nossal and Joshua Lederberg showed that one B cell always produces only one antibody, which was the first evidence for clonal selection theory.
Read more about this topic: Clonal Selection
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