Pathophysiology
The pathogenesis (or the mechanisms that cause) chronic fatigue syndrome are currently unknown despite extensive research, though various possibilities have been proposed. Research studies have examined and hypothesized about the possible etiological characteristics of the disease, including oxidative stress, genetic predisposition, infection by viruses and pathogenic bacteria, hypothalamic-pituitary-adrenal axis abnormalities, immune dysfunction as well as psychological and psychosocial factors. Although it is unclear which factors are a cause or consequence of CFS, various models are proposed.
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