The chronic endothelial injury hypothesis is one of two major mechanisms postulated to explain the underlying cause of atherosclerosis and coronary heart disease (CHD), the other being the lipid hypothesis. Although an ongoing debate involving connection between dietary lipids and CHD sometimes portrays the two hypotheses as being opposed, they are in no way mutually exclusive. Moreover, since the discovery of the role of LDL cholesterol (LDL-C) in the pathogenesis of atherosclerosis, the two hypotheses have become tightly linked by a number of molecular and cellular processes.
Read more about Chronic Endothelial Injury Hypothesis: Origins of The Hypothesis, The Inflammatory Process, The Role of Oxidized LDL, Implications For The Treatment and Prevention of Arteriosclerosis, Implications For Diet: Dietary Lipids and LDL Levels, The AHA Guidelines and The Beginning of A Controversy, Criticism of The AHA Guidelines: The “Cholesterol Skeptics”
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