The chronic endothelial injury hypothesis is one of two major mechanisms postulated to explain the underlying cause of atherosclerosis and coronary heart disease (CHD), the other being the lipid hypothesis. Although an ongoing debate involving connection between dietary lipids and CHD sometimes portrays the two hypotheses as being opposed, they are in no way mutually exclusive. Moreover, since the discovery of the role of LDL cholesterol (LDL-C) in the pathogenesis of atherosclerosis, the two hypotheses have become tightly linked by a number of molecular and cellular processes.
Read more about Chronic Endothelial Injury Hypothesis: Origins of The Hypothesis, The Inflammatory Process, The Role of Oxidized LDL, Implications For The Treatment and Prevention of Arteriosclerosis, Implications For Diet: Dietary Lipids and LDL Levels, The AHA Guidelines and The Beginning of A Controversy, Criticism of The AHA Guidelines: The “Cholesterol Skeptics”
Famous quotes containing the words chronic, injury and/or hypothesis:
“Or would interior time, that could delay
The sentence chronic with the last assize,
Start running backwards with its timely lies,
I might have time to live the love I say....”
—Allen Tate (1899–1979)
“This is ... a trait no other nation seems to possess in quite the same degree that we do—namely, a feeling of almost childish injury and resentment unless the world as a whole recognizes how innocent we are of anything but the most generous and harmless intentions.”
—Eleanor Roosevelt (1884–1962)
“On pragmatistic principles, if the hypothesis of God works satisfactorily in the widest sense of the word, it is true.”
—William James (1842–1910)