The chronic endothelial injury hypothesis is one of two major mechanisms postulated to explain the underlying cause of atherosclerosis and coronary heart disease (CHD), the other being the lipid hypothesis. Although an ongoing debate involving connection between dietary lipids and CHD sometimes portrays the two hypotheses as being opposed, they are in no way mutually exclusive. Moreover, since the discovery of the role of LDL cholesterol (LDL-C) in the pathogenesis of atherosclerosis, the two hypotheses have become tightly linked by a number of molecular and cellular processes.
Read more about Chronic Endothelial Injury Hypothesis: Origins of The Hypothesis, The Inflammatory Process, The Role of Oxidized LDL, Implications For The Treatment and Prevention of Arteriosclerosis, Implications For Diet: Dietary Lipids and LDL Levels, The AHA Guidelines and The Beginning of A Controversy, Criticism of The AHA Guidelines: The “Cholesterol Skeptics”
Famous quotes containing the words chronic, injury and/or hypothesis:
“Or would interior time, that could delay
The sentence chronic with the last assize,
Start running backwards with its timely lies,
I might have time to live the love I say....”
—Allen Tate (1899–1979)
“The legitimate powers of government extend to such acts only as are injurious to others. But it does me no injury for my neighbour to say there are twenty gods, or no god. It neither picks my pocket nor breaks my leg.”
—Thomas Jefferson (1743–1826)
“Oversimplified, Mercier’s Hypothesis would run like this: “Wit is always absurd and true, humor absurd and untrue.””
—Vivian Mercier (b. 1919)