The chronic endothelial injury hypothesis is one of two major mechanisms postulated to explain the underlying cause of atherosclerosis and coronary heart disease (CHD), the other being the lipid hypothesis. Although an ongoing debate involving connection between dietary lipids and CHD sometimes portrays the two hypotheses as being opposed, they are in no way mutually exclusive. Moreover, since the discovery of the role of LDL cholesterol (LDL-C) in the pathogenesis of atherosclerosis, the two hypotheses have become tightly linked by a number of molecular and cellular processes.
Read more about Chronic Endothelial Injury Hypothesis: Origins of The Hypothesis, The Inflammatory Process, The Role of Oxidized LDL, Implications For The Treatment and Prevention of Arteriosclerosis, Implications For Diet: Dietary Lipids and LDL Levels, The AHA Guidelines and The Beginning of A Controversy, Criticism of The AHA Guidelines: The “Cholesterol Skeptics”
Famous quotes containing the words chronic, injury and/or hypothesis:
“Adder-faced singularity
Espouses a nailed-up childhood,
Skin-disease pardons
Soft horror of living,
A gabble is forgiven
By chronic solitude.”
—Philip Larkin (1922–1986)
“A trait no other nation seems to possess in quite the same degree that we do—namely, a feeling of almost childish injury and resentment unless the world as a whole recognizes how innocent we are of anything but the most generous and harmless intentions.”
—Eleanor Roosevelt (1884–1962)
“The hypothesis I wish to advance is that ... the language of morality is in ... grave disorder.... What we possess, if this is true, are the fragments of a conceptual scheme, parts of which now lack those contexts from which their significance derived. We possess indeed simulacra of morality, we continue to use many of the key expressions. But we have—very largely if not entirely—lost our comprehension, both theoretical and practical, of morality.”
—Alasdair Chalmers MacIntyre (b. 1929)