Chem may refer to:
- Chemistry
- Post apocalyptic slang for "drugs", medicinal or otherwise in the Fallout video game series.
In Ancient Egyptian usage:
- Khem (also spelt Chem), the Egyptian word for "black"
- Min (god), in the past erroneously named Khem
CHEM may refer to :
- A metabolic panel: for instance, CHEM-7, which is the basic metabolic panel
- CHEM-TV, a Canadian television channel