Active Site

In biology the active site is part of an enzyme where substrates bind and undergo a chemical reaction. The majority of enzymes are proteins but RNA enzymes called ribozymes also exist. The active site of an enzyme is usually found in a cleft or pocket that is lined by amino acid residues (or nucleotides in ribozymes) that participate in recognition of the substrate. Residues that directly participate in the catalytic reaction mechanism are called active site residues.

Read more about Active SiteBinding Mechanism, Chemistry

Other articles related to "active site, site, sites":

Animal Heme-dependent Peroxidases - Active Site
... The cyclooxygenase active site, which catalyzes the formation of prostaglandin G2 (PGG2) from arachidonic acid, resides at the apex of a long hydrophobic channel ... The peroxidase active site, which catalyzes the reduction of PGG2 to PGH2, is located on the other side of the molecule, at the heme binding site ...
ADP-ribose Diphosphatase - Structure
... structural domains and with two equivalent catalytic sites ... enzyme, but it should also be noted that both domains are involved in the active site and they both help with the attachment and coordination of H2O, Mg2+, and the ADP-ribose substrate ... The picture to the right shows the active site of ADPRase in complex with AMPCPR and Mg2+ ...
Steroid Delta-isomerase - Mechanism
... positioned deep within the hydro-phobic active site and form a so-called oxanion hole ... The active site pit is lined with hydrophobic residues, but there exists an ionic residue, Asp-99, located adjacent to Tyr-14 and within hydrogen bonding distance ... physical changes occur upon steroid binding within the KSI active site ...
Active Site - Chemistry
... Substrates bind to the active site of the enzyme or a specificity pocket through hydrogen bonds, hydrophobic interactions, temporary covalent interactions (van ... Residues of the active site will act as donors or acceptors of protons or other groups on the substrate to facilitate the reaction ... In other words, the active site modifies the reaction mechanism in order to change the activation energy of the reaction ...
Serine Dehydratase - Evolution
... Thus, in PLP enzymes, there is high conservation of the active site residues during evolution ... With active site sequence conservation, it is suggested that dehydratase enzymes originated from a common ancestor ... attached via an imine bond to the amino group in the active site ...

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