Composition
The basement membrane is the fusion of two lamina, the basal lamina and the reticular lamina (or lamina reticularis). The lamina reticularis is attached to the basal lamina with anchoring fibrils (type VII collagen fibers) and microfibrils (fibrillin). The two layers are collectively known as the basement membrane.
The basal lamina layer can further be divided into two layers. The clear layer closer to the epithelium is called the lamina lucida, while the dense layer closer to the connective tissue is called the lamina densa. The electron-dense lamina densa membrane is about 30–70 nanometers in thickness, and consists of an underlying network of reticular collagen (type IV) fibrils (fibroblast precursors) which average 30 nanometers in diameter and 0.1–2 micrometers in thickness. In addition to collagen, this supportive matrix contains intrinsic macromolecular components.
The Lamina Densa (which is made up of type IV collagen fibers; perlecan (a heparan sulfate proteoglycan) coats these fibers and they are high in heparan sulfate) and the Lamina Lucida (made up of laminin, integrins, entactins, and dystroglycans) together make up the basal lamina.
Integrins are not part of the basement lamina, they are part of desmisomes which are in the basement membrane but not the basement lamina. To represent the above in a visually organised manner, the basement membrane is organized as follows:
- Epithelial Tissue (outer)
Read more about this topic: Basement Membrane
Famous quotes containing the word composition:
“There is singularly nothing that makes a difference a difference in beginning and in the middle and in ending except that each generation has something different at which they are all looking. By this I mean so simply that anybody knows it that composition is the difference which makes each and all of them then different from other generations and this is what makes everything different otherwise they are all alike and everybody knows it because everybody says it.”
—Gertrude Stein (1874–1946)
“It is my PRIDE, my damn’d, native, unconquerable Pride, that plunges me into Distraction. You must know that 19-20th of my Composition is Pride. I must either live a Slave, a Servant; to have no Will of my own, no Sentiments of my own which I may freely declare as such;Mor DIE—perplexing alternative!”
—Thomas Chatterton (1752–1770)
“Pushkin’s composition is first of all and above all a phenomenon of style, and it is from this flowered rim that I have surveyed its seep of Arcadian country, the serpentine gleam of its imported brooks, the miniature blizzards imprisoned in round crystal, and the many-hued levels of literary parody blending in the melting distance.”
—Vladimir Nabokov (1899–1977)