Structure
The axon hillock has a number of specialized properties that make it capable of action potential generation, including adjacency to the axon and a much higher density of voltage-gated ion channels than is found in the rest of the cell body. In electrophysiological models, the axon hillock is lumped in with the initial segment of the axon where membrane potentials propagated from synaptic inputs to the dendrites or cell body are summed. In dorsal root ganglion cells, the cell body is thought to have approximately 1 voltage-gated sodium channel per square micrometre, while the axon hillock and initial segment of the axon have about ~100-200 voltage-gated sodium channels per square micrometre; in comparison, the nodes of Ranvier along the axon are thought to have ~1000-2000 such channels per square micrometre. This clustering of voltage-gated ion channels is a consequence of plasma-membrane and cytoskeletal associating proteins such as ankyrin.
Read more about this topic: Axon Hillock
Famous quotes containing the word structure:
“The philosopher believes that the value of his philosophy lies in its totality, in its structure: posterity discovers it in the stones with which he built and with which other structures are subsequently built that are frequently better—and so, in the fact that that structure can be demolished and yet still possess value as material.”
—Friedrich Nietzsche (1844–1900)
“A structure becomes architectural, and not sculptural, when its elements no longer have their justification in nature.”
—Guillaume Apollinaire (1880–1918)
“With sixty staring me in the face, I have developed inflammation of the sentence structure and definite hardening of the paragraphs.”
—James Thurber (1894–1961)