Artemis Entreri is a fictional character in the Forgotten Realms campaign setting for the Dungeons & Dragons fantasy role-playing game. Entreri is depicted as a ruthless assassin and the arch-enemy of Drizzt Do'Urden, the protagonistic dark elf. He is the creation of author R. A. Salvatore, first appearing at the end of the 1988 novel The Crystal Shard, the first book in The Icewind Dale Trilogy. He makes regular reappearances in subsequent novels by Salvatore, reprising his role of main antagonist to the hero Drizzt Do'Urden.
Entreri's character has been well-developed in the series of books by Salvatore as well as in official material for the Forgotten Realms setting itself. Portrayed as a cunning and tactical assassin, Entreri lives an empty life, devoid of any kind of pleasure or companionship, existing only to kill. Credited with being one of the best assassins in Faerûn, he is a highly composed and calculating man, with fighting skills rivaling those of his dark-elven enemy, Drizzt Do'Urden.
Artemis remains one of the most popular D&D characters. He was voted fifth in the "Underdark All-Stars Poll" on Wizards of the Coast's website, and was also rated as one of Dungeons & Dragons' top twenty most infamous and most powerful villains.