The Medical Potential of 4EGI-1
According to Gerhard Wagner, head of the Harvard research group that developed the molecule, the use of 4EGI-1 induced apoptosis in Jurkat Leukemia cells as well as inhibited the proliferation of type A549 lung cancer cells. However, the potency of the drug proved generally ineffective. Researchers remain optimistic that the techniques developed during the discovery of 4EGI-1, such as the high-throughput fluorescence polarization (FP)-binding assay, will ultimately help with the discovery of new drugs.1
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