Zuid-Holland Oost (literally East South Holland) is an official region of the province of South Holland in the Netherlands.
The region consists of the following subregions:
- Alblasserwaard-Vijfheerenlanden, municipalities: Giessenlanden, Gorinchem, Hardinxveld-Giessendam, Leerdam, Molenwaard, and Zederik
- Gouwestreek, municipalities: Bodegraven-Reeuwijk, Boskoop, Gouda, Waddinxveen, and Zuidplas
- Krimpenerwaard, municipalities: Bergambacht, Nederlek, Ouderkerk, Schoonhoven, and Vlist
- Rijnstreek, municipalities: Alphen aan den Rijn, Nieuwkoop, Rijnwoude, and Jacobswoude (former municipality)