Central Pain Syndrome
Central pain syndrome is pain initiated or caused by injury or dysfunction in the central nervous system. Recent research suggests that the development and maintenance of such pain could link to abnormal inhibitory regulation by the zona incerta of the posterior thalamus. It has been suggested that there exists
a significant suppression of both spontaneous and evoked activity in inhibitory neurons in zona incerta and abnormally high spontaneous and evoked activity of neurons in posterior thalamus in animals with central pain syndrome. The positive association between behavioral and neurophysiological thresholds in rats with central pain syndrome is consistent with a causal role for suppressed incerto-thalamic inputs in central pain syndrome.
Read more about this topic: Zona Incerta
Famous quotes containing the words central, pain and/or syndrome:
“It’s easy to forget how central the French people are in everything we mean when we say Europe.”
—John Dos Passos (1896–1970)
“I have given my pain a name and call it “dog”Mit is every bit as faithful, every bit as nosey and shameless, every bit as entertaining, every bit as clever as any other dog—and I can boss it around and vent my bad moods on it, just as others do with their dogs, servants, and wives.”
—Friedrich Nietzsche (1844–1900)
“[T]he syndrome known as life is too diffuse to admit of palliation. For every symptom that is eased, another is made worse. The horse leech’s daughter is a closed system. Her quantum of wantum cannot vary.”
—Samuel Beckett (1906–1989)