Zaca may refer to:
- Huehue Zaca, a 15th century Aztec noble and a warrior.
- The Zaca Fire, the second largest wildfire in modern California history.
- Zaca Creek, an American country music group.
- Zaca Creek, a tributary of the Santa Ynez River.
- Zaca Oil Field, along Zaca Creek.
- Two U.S. Navy ships named USS Zaca.