Yitzhak (יִצְחָק ) is Hebrew for Isaac and may refer to:
- Isaac, the Biblical figure
- A number of public figures in Israel, including
- Yitzhak Ben-Aharon (1906–2006), politician
- Yitzhak Ben-Zvi (1884–63), President of Israel and historian
- Yitzhak Danziger (1916–77), Israeli sculptor
- Yitzhak Rabin (1922-95), former Prime Minister
- Yitzhak Sadeh (1890–1952), commander of the Palmach and one of the founders of the Israel Defense Forces
- Yitzhak Shamir (1915-2012), former Prime Minister
- Yitzhak Navon (born 1921), fifth President of Israel
- See listing of all Wikipedia articles starting with Yitzhak
- Yitzhak, a character from the musical Hedwig and the Angry Inch and subsequent film
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