XY Gonadal Dysgenesis - Treatment

Treatment

Upon diagnosis, estrogen and progesterone therapy is typically commenced, prompting the development of female characteristics.

The consequences of streak gonads to a person with Swyer syndrome:

  1. Gonads cannot make estrogen, so the breasts will not develop and the uterus will not grow and menstruate until estrogen is administered. This is often given transdermally.
  2. Gonads cannot make progesterone, so menstrual periods will not be predictable until progestin is administered, still usually as a pill.
  3. Gonads cannot produce eggs so conceiving children naturally is not possible. A woman with a uterus but no ovaries may be able to become pregnant by implantation of another woman's fertilized egg (embryo transfer).
  4. Streak gonads with Y chromosome-containing cells have a high likelihood of developing cancer, especially gonadoblastoma. Streak gonads are usually removed within a year or so of diagnosis since the cancer can begin during infancy.

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