XX male syndrome (also called de la Chapelle syndrome, for a researcher who characterized it in 1972) is a rare sex chromosomal disorder. Usually it is caused by unequal crossing over between X and Y chromosomes during meiosis in the father, which results in the X chromosome containing the normally-male SRY gene. When this X combines with a normal X from the mother during fertilization, the result is an XX male.
This syndrome occurs in approximately four or five in 100,000 individuals, making it less common than Klinefelter syndrome.
Read more about XX Male Syndrome: Presentation, Clinical Diagnosis, Pathophysiology
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