XR or Xr may refer to:
- XL and XR, characters on Buzz Lightyear of Star Command
- XR (Ford Australia), a designation given to some high-performance vehicles sold by Ford Australia
- Cairo (graphics), the original name for a graphics library software
- Cross-reference
- Exchange rate
- Extended release in certain medications, for example Adderall XR
- Extrapolated Runs, a baseball statistic
- Honda XR series, a line of off-road and dual-sport motorcycles manufactured by Honda
- IOS XR, the software for Cisco Systems' high-end carrier-grade routers
- Index register, a type of register of a CPU
- Skywest Airlines's IATA airline code
- labarum, the Chi-Rho monogram of Christ
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