Wycombe may refer to:
- Wycombe, Bucks or High Wycombe, Buckinghamshire, England
- Wycombe (district), a local government district surrounding High Wycombe in Buckinghamshire, England
- Wycombe Rural District, a former local government district
- Wycombe (UK Parliament constituency)
- Wycombe, Pennsylvania, a village in Wrightstown Township, Pennsylvania