WLS may refer to:

  • White light scanner, a device for measuring physical geometry
  • WLS (AM), a radio station (890 AM)
  • WLS-FM, a radio station (94.7 FM)
  • WLS-TV, a television station (channel 7 analog/44 digital)
  • "World's Largest Store", a former slogan of Sears and the origin of the WLS radio and television call signs
  • The Chapman code for the country of Wales
  • Weight loss surgery
  • Weighted least squares, in statistics, a method for model fitting
  • Westchester Library System, in Westchester County, New York
  • Oracle Weblogic Server, a Java application server
  • Windows Live Spaces
  • West London Synagogue
  • WLS Stamping, a metal stamping and manufacturing company
  • Whittier Law School