Academics and Scientists
- William Thompson (naturalist) (1805–1852), Irish ornithologist and botanist
- William Thompson (viticulturist) (fl. 1863), Englishman who developed the Thompson Seedless grape
- William Thompson (philosopher) (1775–1833), Irish political and philosophical writer and social reformer
- William Thomson, 1st Baron Kelvin (1824–1907), also known as Lord Kelvin, British mathematical physicist
- William Forde Thompson, Australian psychologist
- William Hepworth Thompson (1810–1886), English classical scholar and Master of Trinity College, Cambridge University
- William Irwin Thompson (born 1938), American cultural historian, philosopher, poet, novelist, and yogi
- William Oxley Thompson (1855–1933), fifth President of The Ohio State University
- William Robin Thompson (1887–1972), Canadian biologist
- William Y. Thompson (born 1922), American historian
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