William Sheppard may refer to:
- Bill Sheppard (1906–1950), English association footballer.
- William Fleetwood Sheppard, Australian-British mathematician and statistician
- William Henry Sheppard, African-American Presbyterian missionary famous for revealing Belgian atrocities in the Congo Free State
- William Sheppard (lumber merchant), 19th century lumber merchant and member of the Executive Council of Lower Canada
- William Morgan Sheppard, British actor, sometimes credited as W. Morgan Sheppard or simply Morgan Sheppard
- William Bostwick Sheppard (1860–1934), U.S. federal judge