Research
McGinnis studies the evolutionary changes in transcription factors by looking at the Hox genes. His main research has been in Drosophila, comparing Hox genes within that species with Hox genes in other species, to see they are conserved (kept intact) during evolution. He also studies how Hox transcription functions control morphogenesis, and how changes in the Hox proteins, cofactors, and DNA targets affect morphology. One long term objective of the research in his lab is to understand the molecular interactions that underlie functional specificity in the Hox patterning system.
McGinnis is notable for his co-discovery of homeoboxes, with Michael S. Levine.
Read more about this topic: William Mc Ginnis
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