William Ker may refer to:
- William Ker, Lord Ker (d.1618), eldest son of Robert Ker, 1st Earl of Roxburghe
- William Ker, 2nd Earl of Roxburghe (d.1675), Scottish nobleman
- William Paton Ker (1855-1923), Scottish literary scholar and essayist
- William Ker (footballer), Scottish international footballer in 1872
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