William Keane is the name of:
- Bil Keane (1922 – 2011), creator of The Family Circus comic
- William Keane (bishop) (1805–1875), Roman Catholic bishop in Ireland, Bishop of Cloyne
- William Keane (actor) (born 1961), actor that appeared in Cold Feet
- Will Keane (born 1993), English football player who plays for Manchester United F.C.
- Keane (film)