Bussey Institution
In 1908 Castle moved from the Harvard Museum of Comparative Zoology to the Bussey Institution for Applied Biology. There his most famous PhD student was Sewall Wright who graduated in 1915. When the Eugenics Record Office was founded in 1912, he served as a member of its scientific advisory board, and in 1916 he was one of the 10 founders of the scientific journal Genetics.
His work with hooded rats provided important evidence that evolution could occur by the action of selection on small variations in traits. Other biologists (including T. H. Huxley and William Bates) had doubted Darwin's belief in the sufficiency of small variations (acted upon by natural selection over long periods of time) to explain evolution. He realized that the traits acted upon could be multifactorial. (2)
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“No institution will be better than the institutor.”
—Ralph Waldo Emerson (1803–1882)