William Alford may refer to:
- William VanMeter Alford, Jr. admiral in the U.S. Navy
- William P. Alford (born 1948), U.S. legal scholar
- W. R. (Red) Alford (1937–2003), American mathematician
- Sir William Alford, Custos Rotulorum of the East Riding of Yorkshire (served 1626–aft. 1636)