Wilkes may refer to:
- Wilkes, Portland, Oregon, a US neighborhood
- Wilkes (horse) (born 1952), Australian thoroughbred, sire of Vain (horse)
- USS Wilkes (DD-441), a US Navy destroyer
- Wilkes University, in Pennsylvania, US
- Wilkes Honors College, in Florida, US
- Wilkes (surname), people with the surname Wilkes
- Wilkes Journal-Patriot, a newspaper based in North Wilkesboro, Wilkes County, North Carolina