Wiley Protocol - Specific Dosing

Specific Dosing

The Wiley Protocol uses bioidentical hormones, specifically estradiol and progesterone. Hormones are applied transdermally, using an oil-based skin cream for topical administration. Doses of the hormones vary throughout a 28-day cycle that is designed to mimic the hormone levels and changes of a young woman who experiences regular menstruation, with each hormone cycling and peaking at separate times throughout the period. The protocol is promoted as differing from conventional hormone replacement therapy in several ways:

• The use of plant-derived hormones that are identical to endogenous hormones found in the body, rather than the synthetic derivatives of conventional hormone replacement therapy such as premarin
• A dose that varies over a 28-day cycle rather than remaining static
• Topical rather than oral administration

The protocol also includes a follow-up program to monitor the serum of the bioidentical hormones.

Wiley has stated that in her opinion, the most important aspect of the protocol is the specific schedule and levels of the hormone doses rather than their bioidentical nature.

A patent was granted for the protocol in 2011 for the specific blend of hormones and dosing method.