Wickliffe may refer to:
- people
- Charles A. Wickliffe (1788—1869), a U.S. Representative from Kentucky
- John Wickliffe, a spelling variant of John Wycliffe, 14 Century theologian
- Robert C. Wickliffe, (1819—1895), Lieutenant Governor and Governor of Louisiana
- Robert Charles Wickliffe, (1874–1912, grandson of Charles A. Wickliffe and cousin of John Crepps Wickliffe Beckham), a U.S. Representative from Louisiana
- in Australia
- Wickliffe, Victoria
- in the United States
- Wickliffe, Indiana
- Wickliffe, Kentucky
- Wickliffe (New Roads, Louisiana), listed on the National Register of Historic Places in Pointe Coupee Parish, Louisiana
- Wickliffe, Ohio
- Wickliffe, Oklahoma
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