Current Research
One possible way to accomplish the cost-effective high-throughput sequencing necessary to accomplish full genome sequencing is by using nanopore technology, which is a patented technology held by Harvard University and Oxford Nanopore Technologies and licensed to biotechnology companies. To facilitate their full genome sequencing initiatives, Illumina licensed nanopore sequencing technology from Oxford Nanopore Technologies and Sequenom licensed the technology from Harvard University.
Another possible way to accomplish cost-effective high-throughput sequencing is by utilizing fluorophore technology. Pacific Biosciences is currently using this approach in their SMRT (single molecule real time) DNA sequencing technology.
Complete Genomics has developed DNA Nanoball (DNB) technology that arranges DNA on self-assembling arrays. Complete Genomics' sequencing technology combines its DNB arrays with its proprietary cPAL read technology.
Pyrosequencing is a method of DNA sequencing based on the sequencing by synthesis principle. The technique was developed by Pål Nyrén and his student Mostafa Ronaghi at the Royal Institute of Technology in Stockholm in 1996, and is currently being used by 454 Life Sciences as a basis for a full genome sequencing platform.
Read more about this topic: Whole Genome Sequencing
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