Signs and Symptoms
The most common symptoms are diarrhea, abdominal pain, weight loss and joint pains. Sometimes, the joint pains occur many years before any digestive tract symptoms develop; they tend to involve the large joints but can occur in any pattern and tend not to damage the joint surface to the point that the joint becomes deformed. Fever and chills occur in a small proportion of people.
In its more advanced form, malabsorption (insufficient absorption of nutrients from the diet) leads to wasting and the enlargement of lymph nodes in the abdomen. Neurological symptoms (discussed below) are more common in those with severe abdominal disease. The poor absorption of fat means that many develop steatorrhea (fatty, offensive stool). Depletion of albumin, a blood protein, causes peripheral oedema.
Darkening of the skin occurs in almost half; some also have skin nodules. Various eye problems, such as uveitis, may occur; this is typically associated with deteriorating vision and pain in the affected eye. Endocarditis (infection of the heart valve) has been reported in a small number of cases, sometimes in people with no other symptoms of Whipple's disease; this is typically noticed as breathlessness and leg swelling due to fluid accumulation as the heart is unable to pump fluid through the body.
10–40% of people with Whipple's disease have problems related to involvement of the brain; the symptoms relate to the part of the brain that is affected. The most common problems are dementia, memory loss, confusion, and decreased level of consciousness. Eye movement disturbances and myorhythmia (rapidly repetitive movements of the muscles) of the face, together referred to as oculomasticatory myorhythmia, are highly characteristic for Whipple's disease. Weakness and poor coordination of part of the body, headaches, seizures, as well as a number of more uncommon neurological features, are present in some cases.
Read more about this topic: Whipple's Disease
Famous quotes containing the words signs and/or symptoms:
“Chaucer sawed life in half and out tumbled hundreds of unpremeditated lives, because he didn’t have the cast-iron grid of a priori coherence that makes reading Goethe, Shakespeare, or Dante an exercise in searching for signs of life among the conventions, compulsions, self-justifications, proofs, wise saws, simple but powerful messages, and poetry.”
—Marvin Mudrick (1921–1986)
“The human condition is such that pain and effort are not just symptoms which can be removed without changing life itself; they are the modes in which life itself, together with the necessity to which it is bound, makes itself felt. For mortals, the “easy life of the gods” would be a lifeless life.”
—Hannah Arendt (1906–1975)