Wexler may refer to:
In people with the surname:
- Aaron Wexler
- Anne Wexler (1930–2009), political advisor and lobbyist
- Bernardo Wexler (1925–1992), chess International Master
- Dan Wexler, see Icon (band)
- David Wexler, American law professor
- Donald Wexler, American architect
- Eleonora Wexler, Argentine actress
- Elmer Wexler, American graphic designer
- Glen Wexler, American photographer
- Glenn Wexler, American contemporary artist
- Harry Wexler (1911–1962), American meteorologist
- Haskell Wexler (born 1922), American cinematographer and director
- Ian Wexler, soccer player
- Jerrold Wexler (1924–1992), American businessman
- Jerry Wexler (1917–2008), American music writer and producer
- Jonathan Wexler, Canadian actor
- Karen Wexler, fictional soap opera character
- Leonard D. Wexler, American judge
- Nancy Wexler, geneticist, discoverer of the gene that causes Huntington's disease
- Natalie Wexler
- Norman Wexler
- Paul Wexler (actor) (1929–1979), American actor
- Paul Wexler (linguist), Israeli linguist
- Robert Freeman Wexler, American writer
- Robert Wexler (rabbi), university president
- Robert Wexler, American politician
- Sy Wexler, American film maker
- Victor Raider-Wexler, American television and film actor
In other uses:
- Mount Wexler, United States
- Wexler (crater), lunar impact crater