Wapakoneta may refer to:
- People
- Wapakoneta (Shawnee chief), a Shawnee chief
- Places
- Wapakoneta, Ohio, the home town of Neil Armstrong, the first man on the moon
- The Wapakoneta, Ohio Micropolitan Statistical Area
- The Lima-Van Wert-Wapakoneta, Ohio Combined Statistical Area
- Ships
- USS Wapakoneta, United States Navy ships
- Other
- The Treaty of Wapakoneta
- The Wapakoneta City School District of Wapakoneta, Ohio