Simplest Example
Suppose there is a population, with allele frequencies of A and a given by and respectively . Suppose this population is split into two equally-sized subpopulations, and, and that all the A alleles are in subpopulation and all the a alleles are in subpopulation (this could easily occur due to drift). Then, there are no heterozygotes, even though the subpopulations are in a Hardy-Weinberg equilibrium.
Read more about this topic: Wahlund Effect
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