VSL may refer to:
- vario sureno loco
- Vernon Systems Ltd, a museums collections management software company based in New Zealand
- Very Short List, a pop culture E-mail feed
- Virtual Switch Link, from Cisco
- Variable speed of light, a theory in physics
- Venezuelan Summer League, a Minor League Baseball rookie league in Venezuela
- Vienna Symphonic Library, a library of musical instrument samples
- Virtual Steganographic Laboratory, a software application for steganography and steganalysis
- Visio Solution Library, for Microsoft Visio application
- VSL, the NYSE stock ticker symbol of Videsh Sanchar Nigam Limited
- Vorspann System Losinger, VSL an international post-tensioning specialist contractor owned by Bouygues
- Volume of the Sacred Law, in Freemasonry
- Value of a Statistical Life, or simply Value of life
- Variable Symbol Length, in Telecommunications
- Vanderbilt Sports Line, a sports blog covering Vanderbilt University athletics