VPD may refer to:
- Vancouver Police Department
- Virtual private database
- Vital Product Data, an AIX terminology
- Virtual Product Development
- Vapour Pressure Deficit, a measure of the difference between air humidity and saturation
- Ventricular Premature Depolarization (Premature ventricular contraction, PVC), an untimely action of the heart
- Vapour phase decomposition, a method used in the semiconductor industry