VMC may refer to:
- Vasomotor center, a portion of the medulla oblongata that regulates blood pressure and other homeostatic processes
- Vertical machining center, a vertical milling machine with computer numerical control
- Vevey–Montreux–Chillon tramway, a former tramway in the Swiss canton of Vaud
- Vista Media Center, the Windows Media Center included with Windows Vista
- Visual meteorological conditions, an aviation flight category in which visual flight rules flight is permitted
- VMC speed, the minimum control speed of an aircraft with its critical engine inoperative
- VMC Consulting, a technology consulting company based in Redmond, Washington
- Vodafone Mobile Connect, an internet service provided over a 3G HSDPA network via a PC Card
- Voxel Monte Carlo, a fast voxel-based Monte Carlo simulation code for radiation dose calculation in radiation therapy
- Vruwink MotorCycles, a Sidecarcross frame manufacturer
- Virtual Memory Card, PlayStation 1 or PlayStation 2 emulation.
- Virtual Machine Configuration File
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