Vitamin K Antagonist - Other VKAs

Other VKAs

Not all VKAs are coumarins. For example, fluindione is a VKA, but not a coumarin.

Another example is phenindione.

Many of the non-coumarin VKAs are 1,3-indandione derivatives. Nevertheless, all of these molecules share the same mechanism of action, and are inhibitors (antagonists) of vitamin K epoxide reductase, even though loosely called "vitamin K antagonists." The action of all of them may be antagonized by administration of vitamin K.

• Phenindione

• Clorindione

• Diphenadione